If the game is launched from Steam's Big Picture Mode however, the mouse will move but like it used to be, still cannot interact with the UI. I'm finding that if Warframe is launched from desktop, I can freely use the mouse or new gamepad cursor UI fine. Mouse in the UI is the case in point here. The problem with this classically is that while some base PC controls remain functioning, others like the UI do not. Hopefully in the near future as the new UI comes to fruition entirely, we'll see this removed entirely, but as some, especially Steam Controller users may know, Warframe classically launches in a more gamepad oriented mode if launched from Steam's Big Picture Mode, as opposed to desktop.